The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model
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چکیده
منابع مشابه
P183: Key Function of Complement System in Interactions between Pain and Nociceptors, C5a, and C3a
A part of the immune system that improves (complements) the ability of antibodies and phagocytic cells to clear microorganisms and injured cells from an organism, attacks the pathogen's cell membrane, and encourages inflammation called complement system. It is main part of immune system. Over thirty proteins and protein pieces compose the complement system, including cell membrane receptors, an...
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BACKGROUND Complement has been implicated in the pathogenesis of intestinal damage and inflammation in multiple animal models. Although the exact mechanism is unknown, inhibition of complement prevents hemodynamic alterations in hemorrhage. MATERIALS AND METHODS C57Bl/6, complement 5 deficient (C5-/-) and sufficient (C5+/+) mice were subjected to 25% blood loss. In some cases, C57Bl/6 mice we...
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چکیده ندارد.
15 صفحه اولParoxetine Attenuates the Development and Existing Pain in a Rat Model of Neurophatic Pain
Background: P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could ...
متن کاملPersistent postsurgical and posttrauma pain.
IT IS ESTIMATED that as many as 50% of patients who have undergone surgery experience persistent pain long after the expected postoperative recovery period, and in 2% to 10% of these individuals, the intensity of the pain is severe (see Table 1 for incidence associated with various surgical procedures). This type of pain is common in chronic pain centers, where as many as 20% of individuals see...
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ژورنال
عنوان ژورنال: Pain
سال: 2012
ISSN: 0304-3959
DOI: 10.1016/j.pain.2011.10.032